Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages.

@article{Horton1998HyaluronanFS,
  title={Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages.},
  author={Maureen R. Horton and Chad Mckee and Clare Bao and Fang Liao and Joshua M Farber and J Hodge-Dufour and Ellen Pur{\'e} and Bonnie L Oliver and Tricia M. Wright and Paul W. Noble},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 52},
  pages={35088-94}
}
Hallmarks of chronic inflammation and tissue fibrosis are increased influx of activated inflammatory cells, mediator release, and increased turnover and production of the extracellular matrix (ECM). Recent evidence has suggested that fragments of the ECM component hyaluronan play a role in chronic inflammation by inducing macrophage expression of chemokines. Interferon-gamma (IFN-gamma), an important regulator of macrophage functions, has been shown to induce the C-X-C chemokines Mig and IP-10… CONTINUE READING