Hyaluronan-coated nanoparticles: the influence of the molecular weight on CD44-hyaluronan interactions and on the immune response.

@article{Mizrahy2011HyaluronancoatedNT,
  title={Hyaluronan-coated nanoparticles: the influence of the molecular weight on CD44-hyaluronan interactions and on the immune response.},
  author={Shoshy Mizrahy and Sabina Rebe Raz and Martin Hasgaard and Hong Liu and Neta Soffer-Tsur and Keren Cohen and Ram Dvash and Dalit Landsman-Milo and Maria Gabri{\"e}lle Eleonore Gerarda Bremer and Seyed Moein Moghimi and Dan Peer},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2011},
  volume={156 2},
  pages={231-8}
}
Hyaluronan (HA), a naturally occurring glycosaminoglycan, exerts different biological functions depending on its molecular weight ranging from 4000-10M Da. While high Mw HA (HMw-HA) is considered as anti-inflammatory, low Mw HA (LMw-HA) has been reported to activate an innate immune response. In addition, opposing effects on cell proliferation mediated by the HA receptor CD44, have also been reported for high and low Mw HA. We have previously demonstrated that HMw-HA can be covalently attached… CONTINUE READING
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