Hyaluronan cell surface binding is induced by type I collagen and regulated by caveolae in glioma cells.

@article{Annabi2004HyaluronanCS,
  title={Hyaluronan cell surface binding is induced by type I collagen and regulated by caveolae in glioma cells.},
  author={Borhane Annabi and S{\'e}bastien Thibeault and Robert A. Moumdjian and Richard B{\'e}liveau},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 21},
  pages={
          21888-96
        }
}
Hyaluronan (HA) is a component of the brain extracellular matrix environment that is synthesized and secreted by glioma cells. The primary cell surface receptor for HA is CD44, a membrane glycoprotein that is functionally regulated by a membrane type 1 matrix metalloproteinase (MT1-MMP). Both CD44 and MT1-MMP are partially located in Triton X-100-insoluble domains, but no functional link has yet been established between them. In the present study, we studied the regulation of HA cell surface… CONTINUE READING

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GliomaNo subtypeNeoplasms
Additionally , we describe a new molecular mechanism regulating the invasive potential of glioma cells involving a MT1-MMP / CD44/caveolin interaction , which could represent a potential target for anti - cancer therapies .
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