Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54.

@article{Lisignoli2006HyaluronanbasedPS,
  title={Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54.},
  author={Gina Lisignoli and Sandra Cristino and Anna Piacentini and Carola Cavallo and Arnold I Caplan and Andrea Facchini},
  journal={Journal of cellular physiology},
  year={2006},
  volume={207 2},
  pages={364-73}
}
Hyaluronan (HA), in the bone marrow stroma, is the major non-protein glycosaminoglycan component of extracellular matrix (ECM) involved in cell positioning, proliferation, differentiation as well as in receptor-mediated changes in gene expression. Repair of bone and regeneration of bone marrow is dependent on ECM, inflammatory factors, like chemokines and degradative factors, like metalloproteinases. We analyzed the interaction between human mesenchymal stem cells (h-MSCs) and a three… CONTINUE READING