Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapy.

@article{Meo2007HyaluronanAC,
  title={Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapy.},
  author={Chiara Di Meo and Luigi Panza and Donatella Capitani and Luisa Mannina and Alessandra Banzato and Maria Beatrice Rondina and Davide Renier and Antonio Rosato and Vittorio Crescenzi},
  journal={Biomacromolecules},
  year={2007},
  volume={8 2},
  pages={552-9}
}
Boron neutron capture therapy (BNCT) represents a promising approach for tumor therapy. A critical requirement for BNCT is tumor targeting, a goal that is currently addressed with the development of low and high molecular weight agents capable of interacting with receptors expressed by cancer cells. Here, we describe a new bioconjugate (HApCB) composed by n-propyl carborane linked to hyaluronan (HA) via an ester linkage for a degree of substitution of approximately 30%, leading to a water… CONTINUE READING
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