Hyaluronan as a therapeutic target in human diseases.

@article{Liang2016HyaluronanAA,
  title={Hyaluronan as a therapeutic target in human diseases.},
  author={Jiurong Liang and Dianhua Jiang and Paul W. Noble},
  journal={Advanced drug delivery reviews},
  year={2016},
  volume={97},
  pages={
          186-203
        }
}
Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix and plays an important role in regulating tissue injury and repair, and controlling disease outcomes. The function of hyaluronan depends on its size, location, and interactions with binding partners. While fragmented hyaluronan stimulates the expression of an array of genes by a variety of cell types regulating… CONTINUE READING
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