Hyaluronan and hyaluronidase, which is better for embryo development?

@article{Marei2016HyaluronanAH,
  title={Hyaluronan and hyaluronidase, which is better for embryo development?},
  author={W. F. Marei and K. Raheem and M. Salavati and T. Tremaine and M. Khalid and A. Fouladi-Nashta},
  journal={Theriogenology},
  year={2016},
  volume={86 4},
  pages={
          940-948
        }
}
  • W. F. Marei, K. Raheem, +3 authors A. Fouladi-Nashta
  • Published 2016
  • Biology, Medicine
  • Theriogenology
  • Our aim was to examine size-specific effects of Hyaluronan (HA) on preimplantation embryo development. We investigated the effects of Hyalovet (HA, 500-750 kDa; the size produced by HA synthase-3, which is abundant in the oviduct), or HA treated with Hyaluronidase-2 (Hyal2; also expressed in the oviduct that breaks down HA into 20 kDa fragments). In experiment 1 (in vivo), oviducts of synchronized and superovulated ewes (n = 20) were surgically exposed on Day 2 post-mating, ligated, and infused… CONTINUE READING
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