Hyaluronan and Human Endothelial Cell Behavior

@article{Genasetti2008HyaluronanAH,
  title={Hyaluronan and Human Endothelial Cell Behavior},
  author={Anna Genasetti and Davide Vigetti and Manuela Viola and Eugenia Karousou and Paola Moretto and Manuela Rizzi and Barbara Bartolini and Moira Clerici and Francesco Pallotti and Giancarlo De Luca and Alberto Passi},
  journal={Connective Tissue Research},
  year={2008},
  volume={49},
  pages={120 - 123}
}
Hyaluronan (HA) is the only nonsulphated glycosaminoglycan of extracellular matrix. In mammals HA is synthesised by three homologues HA synthases: HAS1, HAS2, and HAS3. The HA is daily catabolized by the hyaluronidase enzymes to either oligosaccharides or larger polymer. Despite its simple structure, HA is involved in a great number of biological functions, such as cell proliferation and migration, morphogenesis, wound healing, inflammation, angiogenesis, and tumor growth. Moreover, an… Expand
[Hyaluronic acid: structure, metabolism and implication in cicatrisation].
  • Y. Gall
  • Medicine
  • Annales de dermatologie et de venereologie
  • 2010
TLDR
The tridimensional structure of HA is variable and acts as a framework for cell adhesion and migration and hylaluronic acid is very useful in the biomedical field. Expand
Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes
TLDR
This review will focus on the recent findings regarding the regulation of HA synthesis in human vascular SMCs and the effects of the intracellular HA substrates availability, adenosine monophosphate-activated protein kinase (AMPK), and protein O-GlcNAcylation on the main HA synthetic enzyme (i.e., HAS2) will be discussed. Expand
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TLDR
The primary goal of this review is to critically present the importance of HA molecular size on cellular signaling, functional cell properties, and morphology in normal and pathological conditions, including inflammation and cancer. Expand
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In this review, recent described mechanisms involved in HA synthesis regulation and their role in atherosclerosis outcome and development are presented. Expand
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TLDR
The contents of this review article will be very useful for future researchers to evaluate a simple, reliable and cost saving methods for measuring HA and HASs in human blood and to include them as metabolites for cancer screening. Expand
Dynamic Hyaluronan drives liver endothelial cells towards angiogenesis
TLDR
The elucidation of molecular mechanism (s) responsible for HA mediated regulation of endothelial cells and angiogenesis contributes not only to the understanding the mechanism of disease progression but also offer new avenues for therapeutic intervention. Expand
Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan‐dependent monocyte binding
  • Tiina A. Jokela, Jukka Kuokkanen, +6 authors M. Tammi
  • Chemistry, Medicine
  • Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
  • 2013
TLDR
Mannose seems to suppress wounding‐induced inflammation in skin by attenuating hyaluronan synthesis, which is an inherent feature of wounds and is associated with tissue swelling, epithelial and mesenchymal cell migration and proliferation, and induction of cytokine signaling. Expand
Hyaluroan-regulated lymphatic permeability through S1P receptors is crucial for cancer metastasis
TLDR
Results suggested that S1P receptors may play an important role in HMW-HA-/LMW- HA-mediated regulation of cancer lymphatic vessel integrity, which might be the initial step of cancerymphatic metastasis and a useful intervention of cancer progression. Expand
Role of hyaluronan in angiogenesis and its utility to angiogenic tissue engineering
TLDR
The role and significance of hyaluronan (HA), a glycosaminoglycan (GAG) component of connective tissues, in physiologic and pathologicalAngiogenesis, its applicability as a therapeutic to stimulate or suppress angiogenesis in situ within necrotic tissues in vivo, and the factors determining its potential utility as a pro-angiogenic stimulus that will enable tissue engineering of neo-vascularized and functional tissue constructs for clinical use are provided. Expand
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