Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells

@article{Kothapalli2007HyaluronanAC,
  title={Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells},
  author={Devashish Kothapalli and Liang Zhao and Elizabeth A. Hawthorne and Yan Cheng and Eric A Lee and Ellen Pure and Richard K. Assoian},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={176},
  pages={535 - 544}
}
High molecular weight (HMW) hyaluronan (HA) is widely distributed in the extracellular matrix, but its biological activities remain incompletely understood. We previously reported that HMW-HA binding to CD44 antagonizes mitogen-induced S-phase entry in vascular smooth muscle cells (SMCs; Cuff, C.A., D. Kothapalli, I. Azonobi, S. Chun, Y. Zhang, R. Belkin, C. Yeh, A. Secreto, R.K. Assoian, D.J. Rader, and E. Puré. 2001. J. Clin. Invest. 108:1031-1040); we now characterize the underlying… CONTINUE READING
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