Hyaluronan Signaling during Ozone-Induced Lung Injury Requires TLR4, MyD88, and TIRAP

@inproceedings{Li2011HyaluronanSD,
  title={Hyaluronan Signaling during Ozone-Induced Lung Injury Requires TLR4, MyD88, and TIRAP},
  author={Zhuowei Li and Erin N. Potts-Kant and Stavros Garantziotis and William Michael Foster and John W. Hollingsworth},
  booktitle={PloS one},
  year={2011}
}
Ozone exposure is associated with exacerbation of reactive airways disease. We have previously reported that the damage-associated molecular pattern, hyaluronan, is required for the complete biological response to ambient ozone and that hyaluronan fragments signal through toll-like receptor 4 (TLR4). In this study, we further investigated the role of TLR4 adaptors in ozone-induced airway hyperresponsiveness (AHR) and the direct response to hyaluronan fragments (HA). Using a murine model of AHR… CONTINUE READING
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