Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes.

Abstract

Both hyaluronan [HA, the major glycosaminoglycans in the extracellular matrix (ECM)] and CD44 (a primary HA receptor) are associated with astrocyte activation and tissue repair following central nervous system (CNS) injury. In this study we investigated the question of whether HA-CD44 interaction influences astrocyte signaling and migration. Our data… (More)

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Cite this paper

@article{Bourguignon2007HyaluronanCD44IS, title={Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes.}, author={Lilly Y. W. Bourguignon and Eli Gilad and Karine Peyrollier and Amy Brightman and Raymond A Swanson}, journal={Journal of neurochemistry}, year={2007}, volume={101 4}, pages={1002-17} }