Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells.

@article{Slomiany2009HyaluronanCA,
  title={Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells.},
  author={Mark G. Slomiany and George Grass and Angela D Robertson and Xiao Yi Yang and B. L. Maria and Craig Cano Beeson and Bryan P. Toole},
  journal={Cancer research},
  year={2009},
  volume={69 4},
  pages={1293-301}
}
Interactions of hyaluronan with CD44 in tumor cells play important cooperative roles in various aspects of malignancy and drug resistance. Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglobulin superfamily that is highly up-regulated in malignant cancer cells and stimulates hyaluronan production, as well as several downstream signaling pathways. Emmprin also interacts with various monocarboxylate transporters (MCT). Malignant cancer cells use the glycolytic pathway and… CONTINUE READING
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