Hyaline cytoplasmic inclusions in human hepatoma. A case report.

@article{Grimelius1977HyalineCI,
  title={Hyaline cytoplasmic inclusions in human hepatoma. A case report.},
  author={Lars Grimelius and Unne Stenram and Jan Westman and S. Westman-Naeser},
  journal={Acta cytologica},
  year={1977},
  volume={21 3},
  pages={469-76}
}
A case of hepatoma in a 79-year old woman is reported. The patient had an enlarged liver and a pathological liver scintigram. Percutaneous liver biopsies were performed both with Menghini-and fine needles. The most prominent feature was the presence of hyaline cytoplasmic PAS-negative inclusions in liver parenchymal cells. There was no nuclear atypia. Electron microscopy disclosed two types of cytoplasmic changes. One consisted of a lamellar ultrastructure and was interpreted as a hyperplasia… CONTINUE READING