HyPer Family Probes: State of the Art.

  title={HyPer Family Probes: State of the Art.},
  author={Dmitry S. Bilan and Vsevolod V Belousov},
  journal={Antioxidants & redox signaling},
  volume={24 13},
SIGNIFICANCE Hydrogen peroxide (H2O2) is not only a key mediator of oxidative stress but also one of the most important cellular second messengers. This small short-lived molecule is involved in the regulation of a wide range of different biological processes, including regulation of cellular signaling pathways. Studying the role of H2O2 in living systems would be challenging without modern approaches. A genetically encoded fluorescent biosensor, HyPer, is one of the most effective tools for… CONTINUE READING