Hy's law

  title={Hy's law},
  author={Adrian Reuben},
  • A. Reuben
  • Published 1 February 2004
  • Medicine
  • Hepatology
An alternative organic diet in preventing hyperlipidemia in cholesterol- fed Sprague-Dawley rats by Arthrospira (Spirulina) platensis
Both dosages of Arthrospira displayed tremendous potential as an anti-hyperlipidemic agent in high cholesterol-fed Sprague-Dawley rats.
Assessment of Liver Function in Clinical Practice
A broad array of biochemical tests are used to assess the various functions of the liver and evaluate patients with suspected or established liver disease, and the most commonly used tests are the aminotransferases and alkaline phosphatase.
Idiosyncratic Liver Injury: Challenges and Approaches
The National Institute of Diabetes and Digestive and Kidney Diseases of The National Institutes of Health has recently sponsored a cooperative agreement (UO1) to create a Drug Induced Liver Injury Network (DILIN), which should provide heretofore missing resources required to address the problem.
Evaluating the hepatoprotective, ameliorative and antioxidant potentials of the crude aqueous leafy extracts of Mangifera indica plant against acute paracetamol-induced hepatotoxicity in a mouse model
The findings from this study demonstrated that the crude aqueous leafy extract of M. indica possesses hepatoprotective effect, possibly mediated through the induction of antioxidant enzymes to prevent the occurrence of oxidative stress damage or most likely through the inhibition of pro-inflammatory mediators which are being induced by the lethal hepatotoxic dose of paracetamol.
Incidence of Elevated Aminotransferases With or Without Bilirubin Elevation During Treatment With Immune Checkpoint Inhibitors: A Retrospective Study of Patients From Community Oncology Clinics in the United States
Real-world data from oncology clinics in US suggest low incidence of grade ≥ 3 elevated aminotransferase levels with or without bilirubin elevation following treatment with ICIs.
Indomethacin induced toxic hepatitis: a case report
Effect of exercise and diet intervention in NAFLD and NASH via GAB2 methylation
The susceptibility of DNA methylation in GAB2 to ELFD intervention is highlighted, through which exercise and diet can protect against the progression of NAFLD and NASH on the genome level, andDNA methylation variation in blood could mirror epigenetic signatures in target tissues of important biological function, i.e., liver and adipose tissue.
Drug Induced Liver Injury
  • N. Bergasa
  • Medicine
    Clinical Cases in Hepatology
  • 2021
Early therapeutic plasma exchange may improve treatment outcomes in severe acute toxic Hepatitis.
  • İ. Berber, Y. Cagin, A. Polat
  • Medicine
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • 2021
Modeling approaches for reducing safety-related attrition in drug discovery and development: a review on myelotoxicity, immunotoxicity, cardiovascular toxicity, and liver toxicity
This review was on modeling approaches applied to four kinds of drug-induced toxicities: hematological, immunological, cardiovascular (CV) and liver toxicity, with accuracies in the range of 70–90%.


Lower plants as a source of anticancer drugs.
: The NCI's antineoplastic fermentation program is reviewed. Clinically useful antitumor antibiotics are discussed in terms of their activity, mechanism of action, and the producing microbe.
Medicinals for the Millennia
Abstract: Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional
Incidence of Adverse Drug Events and Potential Adverse Drug Events: Implications for Prevention
Adverse drug events were common and often preventable; serious ADEs were more likely to be preventable and prevention strategies should target both stages of the drug delivery process.
Drug-Related Morbidity and Mortality: A Cost-of-Illness Model
The cost of drug-related morbidity and mortality in the ambulatory setting in the United States is considerable and should be considered in health policy decisions with regard to pharmaceutical benefits.
Results indicative of obstructive jaundice were obtained in some patients, suggesting that icterus following administration of arsphenamine is not always due to liver parenchymal injury but in certain instances is due to obstructive processes.
CRC handbook of ayurvedic medicinal plants
This handbook is filled with over 50 illustrations and descriptions of approximately 250 plants which are used for herbal medicine. It includes the most current information available today on
Drug-induced hepatotoxicity.
  • W. M. Lee
  • Medicine
    The New England journal of medicine
  • 1995
Old drugs, old and new history.
  • J. Riddle
  • History
    Publication - American Institute of the History of Pharmacy
  • 1997