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An alternative organic diet in preventing hyperlipidemia in cholesterol- fed Sprague-Dawley rats by Arthrospira (Spirulina) platensis
This study aimed to investigate the effects of Arthrospira (Spirulina) platensis in high cholesterol-fed Sprague-Dawley rats from a blood biochemistry analysis by evaluating the total cholesterol… Expand
Assessment of Liver Function in Clinical Practice
A broad array of biochemical tests are used to assess the various functions of the liver and evaluate patients with suspected or established liver disease, and the most commonly used tests are the aminotransferases and alkaline phosphatase. Expand
Idiosyncratic Liver Injury: Challenges and Approaches
- Toxicologic pathology
The National Institute of Diabetes and Digestive and Kidney Diseases of The National Institutes of Health has recently sponsored a cooperative agreement (UO1) to create a Drug Induced Liver Injury Network (DILIN), which should provide heretofore missing resources required to address the problem. Expand
A phase 3, multicenter study to assess the 1-year safety and tolerability of a combination of olanzapine and samidorphan in patients with schizophrenia: Results from the ENLIGHTEN-2 long-term extension
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Early therapeutic plasma exchange may improve treatment outcomes in severe acute toxic Hepatitis
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Long-term Treatment with Telotristat Ethyl in Patients with Carcinoid Syndrome Symptoms: Results from the TELEPATH Study.
Introduction: Telotristat ethyl is indicated for use in combination with somatostatin analogs (SSAs) to treat carcinoid syndrome (CS) diarrhea uncontrolled by SSAs alone in adults, but long-term… Expand
Modeling approaches for reducing safety-related attrition in drug discovery and development: a review on myelotoxicity, immunotoxicity, cardiovascular toxicity, and liver toxicity.
- Expert opinion on drug discovery
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Clinical implications of drug‐induced liver injury in early‐phase oncology clinical trials
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Drug-Induced Liver Injury Resources and Reporting for the Clinician.
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This work identifies and summarize the resources available to clinicians to help diagnose, manage, and report DILI and to identify hepatotoxic drugs. Expand
Drug-Induced Liver Injury – Stellenwert der Pathologie
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Der Vorteil der Leberbiopsie gegenüber einer rein klinisch/serologischen Diagnostik liegt in einer genaueren Auflösung mit Hinweisen auf den Schädigungsmechanismus, die Aktivität, die Regenerationsfähigkeit, die Chronifizierung and the Prognose. Expand
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- Clinics in liver disease
Several agents have been used for symptomatic relieve of the pruritus associated with cholestasis, including cholestyramine, ursodeoxycholic acid, and opiate antagonists, with limited results. Expand
Mother nature's combinatorial libraries; their influence on the synthesis of drugs.
- Computer Science, Medicine
- Current opinion in drug discovery & development
Examples of the application of combinatorial methods to nature's combinatorsial library will be presented and discussed, with an emphasis on the antitumor, anti-infective and pain control disease areas. Expand
Incidence of serious adverse drug reactions in general practice: A prospective study
- Clinical pharmacology and therapeutics
The frequency of serious adverse drug reactions in general practice and the impact on the economy of these reactions are well known. Expand
Medicinals for the Millennia
Abstract: Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional… Expand
Drugs and adverse drug reactions: how worried should we be?
Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies.
The incidence of serious and fatal adverse drug reactions in US hospitals was found to be extremely high, and data suggest that ADRs represent an important clinical issue. Expand
Old drugs, old and new history.
- Publication - American Institute of the History of Pharmacy