Hv1 proton channels differentially regulate the pH of neutrophil and macrophage phagosomes by sustaining the production of phagosomal ROS that inhibit the delivery of vacuolar ATPases.

@article{Chemaly2014Hv1PC,
  title={Hv1 proton channels differentially regulate the pH of neutrophil and macrophage phagosomes by sustaining the production of phagosomal ROS that inhibit the delivery of vacuolar ATPases.},
  author={Antoun El Chemaly and Paula Roberta Nunes and Wedali Jimaja and Cyril Castelbou and Nicolas Demaurex},
  journal={Journal of leukocyte biology},
  year={2014},
  volume={95 5},
  pages={827-839}
}
Production of ROS and maintenance of an appropriate pH within the lumen of neutrophil and macrophage phagosomes are important for an effective immune response. Hv1 proton channels sustain ROS production at the plasma membrane, but their role in phagosomes is not known. Here, we tested whether Hv1 channels regulate the pHp and sustain phagosomal ROS production in neutrophils and macrophages. The presence of Hv1 channels on phagosomes of human neutrophils and mouse macrophages was confirmed by… CONTINUE READING
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