Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway

  title={Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway},
  author={Reinoud E. A. de Groot and Ranjani Sri Ganji and Ondřej Bernat{\'i}k and Bethan Lloyd-Lewis and Katja Seipel and Kateřina {\vS}edov{\'a} and Zbyněk Zdr{\'a}hal and Vishnu Mukund Dhople and Trevor C Dale and Hendrik C. Korswagen and V{\'i}tězslav Bryja},
  journal={Science Signaling},
Wnt signaling plays a central role in development, adult tissue homeostasis, and cancer. Several steps in the canonical Wnt/β-catenin signaling cascade are regulated by ubiquitylation, a protein modification that influences the stability, subcellular localization, or interactions of target proteins. To identify regulators of the Wnt/β-catenin pathway, we performed an RNA interference screen in Caenorhabditis elegans and identified the HECT domain–containing ubiquitin ligase EEL-1 as an… CONTINUE READING
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