Hutchinson-Gilford progeria syndrome with severe calcific aortic valve stenosis and calcific mitral valve.

@article{Nair2004HutchinsonGilfordPS,
  title={Hutchinson-Gilford progeria syndrome with severe calcific aortic valve stenosis and calcific mitral valve.},
  author={Krishnakumar R Nair and Padmakumar Ramachandran and Kavassery Mahadevan Krishnamoorthy and Santhosh Kumar Dora and Tharakan J Achuthan},
  journal={The Journal of heart valve disease},
  year={2004},
  volume={13 5},
  pages={866-9}
}
The case of a 12-year-old girl with clinical features of progeria with severe calcific valvar aortic stenosis is presented. The mitral valve showed the presence of calcium, and peripheral vascular disease was also present, though there was no family history of this. Aortic valve replacement was deferred because of insufficient data relating to this condition. The genetics and phenotypic mechanisms of the disease are reviewed. In view of the association of progeria with valve disease, all… CONTINUE READING