Hurdles to the induction of tolerogenic mixed chimerism.


To date, organ transplant patients have to deal with the numerous side effects of life-long dependence on immunosuppressive drugs, whereas at the same time these drugs fail to prevent chronic rejection in many cases. Finding ways to establish donor-specific immunological tolerance thus remains one of the major goals in transplantation medicine. Tolerance… (More)
DOI: 10.1097/TP.0b013e3181a2b9cc