Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide.

@article{Gao2009HuperzineAP,
  title={Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide.},
  author={Xin Gao and Chun Yan Zheng and Ling Yang and Xi Can Tang and Hai Yan Zhang},
  journal={Free radical biology & medicine},
  year={2009},
  volume={46 11},
  pages={1454-62}
}
Our previous work in cells and animals showed that mitochondria are involved in the neuroprotective effect of huperzine A (HupA). In this study, the effects of HupA on isolated rat brain mitochondria were investigated. In addition to inhibiting the Abeta(25-35) (40 microM)-induced decrease in mitochondrial respiration, adenosine 5'-triphosphate (ATP) synthesis, enzyme activity, and transmembrane potential, HupA (0.01 or 0.1 microM) effectively prevented Abeta-induced mitochondrial swelling… CONTINUE READING

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