Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons.

Abstract

The neuroprotection of huperzine A against apoptosis was investigated. In cultures of rat primary cortical neurons, neuronal apoptosis was induced by serum deprivation for 24 h, which was accompanied by enhanced caspase-3 activity and the release of cytochrome c into the cytosol from mitochondria. Pretreating the neurons for 2 h with huperzine A (0.1-10… (More)

Topics

Cite this paper

@article{Zhou2002HuperzineAA, title={Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons.}, author={Jin Zhou and Xi Can Tang}, journal={FEBS letters}, year={2002}, volume={526 1-3}, pages={21-5} }