Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.

@article{Zhou2001HuperzineAA,
  title={Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.},
  author={Jing Zhou and Y M Fu and Xi Can Tang},
  journal={Neuroscience letters},
  year={2001},
  volume={306 1-2},
  pages={53-6}
}
Huperzine A (HupA) and donepezil, two novel selective acetylcholinesterase inhibitors available for Alzheimer's disease, were tested for their ability to alleviate injury from oxygen-glucose deprivation (OGD) in the rat pheochromocytoma line PC12 cells. OGD for 30 min triggered death in more than 50% of cells, along with major changes in morphology and biochemistry including elevated levels of lipid peroxide, superoxide disamutase activity and lactate. Cells pretreated for 2 h with HupA or… CONTINUE READING
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