Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats

@inproceedings{Mao2014HuperzineAA,
  title={Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats},
  author={Xiao-yuan Mao and Dan-feng Cao and Xia Li and Ji-Ye Yin and Zhi-bin Wang and Ying Zhang and Chen-Xue Mao and Hong-hao Zhou and Zhaoqian Liu},
  booktitle={International journal of molecular sciences},
  year={2014}
}
The present study was designed to probe the effects of Huperzine A (HupA) on diabetes-associated cognitive decline (DACD) using a streptozotocin (STZ)-injected rat model. Diabetic rats were treated with HupA (0.05 and 0.1 mg/kg) for seven weeks. Memory functions were evaluated by the water maze test. Nissl staining was selected for detecting neuronal loss. Protein and mRNA levels of brain-derived neurotrophic factor (BDNF) were analyzed by ELISA and real-time PCR, respectively. The activities… CONTINUE READING

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