Huperzine A (shuangyiping): a promising drug for Alzheimer's disease.

  title={Huperzine A (shuangyiping): a promising drug for Alzheimer's disease.},
  author={Xin-hui Tang},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  volume={17 6},
  • Xin-hui Tang
  • Published 1996 in
    Zhongguo yao li xue bao = Acta pharmacologica…
Hup A, a novel alkaloid isolated from Chineses herb Huperzia serrata, is a potent and selective inhibitor of AChE, with a rapid absorption and penetration into the brain in experimental animals. The inhibition is reversible with a longer duration of action. Hup A exhibited memory-enhancing activities in a broad range of animal cognitive model. Compared to Phy, Tac, and Gal, Hup A has better therapeutic indices, and peripheral cholinergic side effects are minimal at therapeutic doses. These… CONTINUE READING

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