Huntington disease.

@article{Kernich2008HuntingtonD,
  title={Huntington disease.},
  author={Catherine Ann Kernich},
  journal={The neurologist},
  year={2008},
  volume={14 6},
  pages={
          399-400
        }
}
Adult-onset Huntington disease, the most common form of this disorder, usually appears in a person's thirties or forties. Early signs and symptoms can include irritability, depression, small involuntary movements, poor coordination, and trouble learning new information or making decisions. Many people with Huntington disease develop involuntary jerking or twitching movements known as chorea. As the disease progresses, these movements become more pronounced. Affected individuals may have trouble… 

References

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Huntington's disease.
Huntington's disease: phenomenological diversity of a neuropsychiatric condition that challenges traditional concepts in neurology and psychiatry.
TLDR
The following case report emphasizes the spectrum and clinical significance of neuropsychiatric phenomena associated with Huntington’s disease and discusses the diagnostic power of specific neuropsychological approaches.
The Clinical and Genetic Features of Huntington Disease
TLDR
An overview of the clinical and genetic features of HD together with a summary of clinical research at this time is provided.
Huntingtin in health and disease.
  • A. Young
  • Biology
    The Journal of clinical investigation
  • 2003
After linkage of the Huntington disease (HD) gene was found in 1983, it took ten years of work by an international group to identify the mutation in the gene interesting transcript 15 (IT15) that
Clinical Characteristics of Childhood-Onset (Juvenile) Huntington Disease: Report of 12 Patients and Review of the Literature
TLDR
The clinical, demographic, and genetic characteristics in 12 patients with childhood-onset Huntington disease are presented and compared with data in the literature, suggesting a differential phenotype within patients with children's Huntington disease depending on the age at onset.
Huntington's disease: from pathology and genetics to potential therapies.
TLDR
Not all of the effects of mutant huntingtin may be cell-autonomous, and it is possible that abnormalities in neighbouring neurons and glia may also have an impact on connected cells.
History of genetic disease: The molecular genetics of Huntington disease — a history
  • G. Bates
  • Medicine, Biology
    Nature Reviews Genetics
  • 2005
TLDR
The Huntington disease gene was mapped to human chromosome 4p in 1983 and 10 years later the pathogenic mutation was identified as a CAG-repeat expansion and powerful genetic models are now equipped that continue to uncover new aspects of the pathogenesis of Huntington disease.