Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study.

@article{McNicoll2008HuntingtonCR,
  title={Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study.},
  author={Christopher F McNicoll and Jeanne Latourelle and Marcy E. MacDonald and Mark F. Lew and Oksana Suchowersky and Christine Klein and Lawrence I. Golbe and Margery H. Mark and John Growdon and G. Frederick Wooten and Ray L. Watts and Mark Guttman and Brad A. Racette and Joel S. Perlmutter and Anwar E Ahmed and Holly Shill and Carlos Singer and Marie-H{\'e}l{\`e}ne Saint-Hilaire and Tiffany Massood and Karen W. Huskey and Anita L. DeStefano and Tammy Gillis and Jayalakshmi Mysore and Stefano Goldwurm and Gianni Pezzoli and Kenneth B. Baker and Ilia Itin and Irene Litvan and Garth A. Nicholson and Alastair J. Corbett and Martha A. Nance and Edward Drasby and Stuart H. Isaacson and David J. Burn and Patrick F. Chinnery and Peter P. Pramstaller and Jomana Al-hinti and Anette T. Moller and Karen Ostergaard and Scott J. Sherman and Richard Roxburgh and Barry Snow and John T. Slevin and Franca Cambi and James F. Gusella and Richard H. Myers},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2008},
  volume={23 11},
  pages={1596-601}
}
The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping… CONTINUE READING

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