Huntington ’ S Disease and Insurance I : a Model of Huntington ’ S Disease

  title={Huntington ’ S Disease and Insurance I : a Model of Huntington ’ S Disease},
  author={Cristina Guti{\'e}rrez and Angus MacDonald}
We review the literature on the epidemiology of Huntington’s disease (HD), a highly penetrant, dominantly inherited, fatal neurological disorder. Although it is a single-gene disorder, mutations are variable in their effects, depending on the number of times that the CAG trinucleotide is repeated in a certain region of the HD gene. Very reliable genetic tests are now available. We fit models: (a) to rates of onset, depending on CAG repeat length as well as age; (b) to post-onset rates of… CONTINUE READING
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