Huntington's disease: a clinical review

@article{McColgan2018HuntingtonsDA,
  title={Huntington's disease: a clinical review},
  author={Peter McColgan and Sarah J. Tabrizi},
  journal={European Journal of Neurology},
  year={2018},
  volume={25}
}
Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on chromosome 4. In Western populations HD has a prevalence of 10.6–13.7 individuals per 100 000. It is characterized by cognitive, motor and psychiatric disturbance. At the cellular level mutant huntingtin results in neuronal dysfunction and death through a number of mechanisms, including disruption of proteostasis, transcription… 
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