Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases

  title={Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases},
  author={Ray Truant and Randy Singh Atwal and Carly R. Desmond and Lise N. Munsie and Thu L Tran},
  journal={The FEBS Journal},
After the successful cloning of the first gene for a polyglutamine disease in 1991, the expanded polyglutamine tract in the nine polyglutamine disease proteins became an obvious therapeutic target. Early hypotheses were that misfolded, precipitated protein could be a universal pathogenic mechanism. However, new data are accumulating on Huntington’s disease and other polyglutamine diseases that appear to contradict the toxic aggregate hypothesis. Recent data suggest that the toxic species of… 

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