Huntington’s Disease Mouse Models Online: High-Resolution MRI Images with Stereotaxic Templates for Computational Neuroanatomy

@inproceedings{Sawiak2012HuntingtonsDM,
  title={Huntington’s Disease Mouse Models Online: High-Resolution MRI Images with Stereotaxic Templates for Computational Neuroanatomy},
  author={Stephen J. Sawiak and Nigel Wood and T. Adrian Carpenter and A. Jennifer Morton},
  booktitle={PloS one},
  year={2012}
}
Magnetic resonance imaging (MRI) has proved to be an ideal modality for non-destructive and highly detailed assessment of structural morphology in biological tissues. Here we used MRI to make a dataset of ex vivo brains from two different rodent models of Huntington's disease (HD), the R6/2 line and the YAC 128 mouse. We are making the whole dataset (399 transgenic HD and wildtype (WT) brains, from mice aged 9-80 weeks) publicly available. These data will be useful, not only to investigators… CONTINUE READING
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