Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood

@inproceedings{Mastrokolias2015HuntingtonsDB,
  title={Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood},
  author={Anastasios Mastrokolias and Yavuz Ariyurek and Jelle J. Goeman and Erik van Duijn and Raymund Roos and R C van der Mast and Gert-Jan van Ommen and Johan T den Dunnen and Peter A C 't Hoen and Willeke M. C. van Roon-Mom},
  booktitle={European Journal of Human Genetics},
  year={2015}
}
With several therapeutic approaches in development for Huntington’s disease, there is a need for easily accessible biomarkers to monitor disease progression and therapy response. We performed next-generation sequencing-based transcriptome analysis of total RNA from peripheral blood of 91 mutation carriers (27 presymptomatic and, 64 symptomatic) and 33 controls. Transcriptome analysis by DeepSAGE identified 167 genes significantly associated with clinical total motor score in Huntington’s… CONTINUE READING
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