Huntington's disease: underlying molecular mechanisms and emerging concepts.

  title={Huntington's disease: underlying molecular mechanisms and emerging concepts.},
  author={John Labbadia and Richard I. Morimoto},
  journal={Trends in biochemical sciences},
  volume={38 8},
Huntington's disease (HD) is a progressive neurodegenerative disorder for which no disease modifying treatments exist. Many molecular changes and cellular consequences that underlie HD are observed in other neurological disorders, suggesting that common pathological mechanisms and pathways may exist. Recent findings have enhanced our understanding of the way cells regulate and respond to expanded polyglutamine proteins such as mutant huntingtin. These studies demonstrate that in addition to… CONTINUE READING
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