Huntington's disease: pathogenesis to animal models.

  title={Huntington's disease: pathogenesis to animal models.},
  author={Puneet Kumar and Harikesh Kalonia and Anil Kumar},
  journal={Pharmacological reports : PR},
  volume={62 1},
Huntington's disease (HD) is an inherited genetic disorder, characterized by cognitive dysfunction and abnormal body movements called chorea. George Huntington, an Ohio physician, described the disease precisely in 1872. HD is a dominantly inherited disorder, characterized by progressive neurodegeneration of the striatum but also involves other regions, primarily the cerebral cortex. The mutation responsible for this fatal disease is an abnormally expanded and unstable CAG repeat within the… CONTINUE READING


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