Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons.

@article{Colin2008HuntingtinPA,
  title={Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons.},
  author={Emilie Colin and Diana Zala and G{\'e}raldine Liot and H{\'e}l{\`e}ne Rangone and Maria Borrell-Pag{\`e}s and Xiao-Jiang Li and Fr{\'e}d{\'e}ric Saudou and Sandrine Humbert},
  journal={The EMBO journal},
  year={2008},
  volume={27 15},
  pages={2124-34}
}
The transport of vesicles in neurons is a highly regulated process, with vesicles moving either anterogradely or retrogradely depending on the nature of the molecular motors, kinesins and dynein, respectively, which propel vesicles along microtubules (MTs). However, the mechanisms that determine the directionality of transport remain unclear. Huntingtin… CONTINUE READING