Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons

  title={Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons},
  author={Bin Ma and Jeffrey N Savas and Man-Shan Yu and Brady P. Culver and Moses V Chao and Naoko Tanese},
  booktitle={Scientific reports},
Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently detected the Huntington's disease protein huntingtin (Htt) in dendritic RNA granules; however, the functional significance of this localization is not known. Here we report that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during… CONTINUE READING
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