Huntingtin is degraded to small fragments by calpain after ischemic injury.

@article{Kim2003HuntingtinID,
  title={Huntingtin is degraded to small fragments by calpain after ischemic injury.},
  author={Manho Kim and J N Roh and Byung Woo Yoon and Lami Kang and Yun Jeong Kim and Neil Aronin and Marian Difiglia},
  journal={Experimental neurology},
  year={2003},
  volume={183 1},
  pages={109-15}
}
The gene defect in Huntington's disease (HD) causes a polyglutamine expansion in the N-terminal region of huntingtin (N-htt). In vitro studies suggest that mutant N-htt fragments can aggregate and cause cell death in HD. The physiological and pathological conditions that affect htt proteolysis in the brain are unclear. We examined htt expression by Western blot in the rat brain after transient ischemic injury, which causes striatal neurodegeneration similar to that seen in HD and activates… CONTINUE READING

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