Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

@article{DiFiglia1995HuntingtinIA,
  title={Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons},
  author={M. DiFiglia and E. Sapp and K. Chase and C. Schwarz and A. Meloni and C. Young and Eileen Martin and J. Vonsattel and R. Carraway and S. Reeves and F. Boyce and N. Aronin},
  journal={Neuron},
  year={1995},
  volume={14},
  pages={1075-1081}
}
The gene defective in Huntington's disease encodes a protein, huntingtin, with unknown function. Antisera generated against three separate regions of huntingtin identified a single high molecular weight protein of approximately 320 kDa on immunoblots of human neuroblastoma extracts. The same protein species was detected in human and rat cortex synaptosomes and in sucrose density gradients of vesicle-enriched fractions, where huntingtin immunoreactivity overlapped with the distribution of… Expand
Analysis of huntingtin‐associated protein 1 in mouse brain and immortalized striatal neurons
Huntingtin localization in brains of normal and Huntington's disease patients
Localization of rabbit huntingtin using a new panel of monoclonal antibodies.
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Huntington's disease gene (IT15) is widely expressed in human and rat tissues
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