Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

@article{Zuccato2003HuntingtinIW,
  title={Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes},
  author={Chiara Zuccato and Marzia Tartari and Andrea Crotti and Donato Goffredo and Marta Valenza and Luciano Conti and Tiziana Cataudella and Blair R. Leavitt and Michael R. Hayden and T{\~o}nis Timmusk and Dorotea Rigamonti and Elena Cattaneo},
  journal={Nature Genetics},
  year={2003},
  volume={35},
  pages={76-83}
}
Huntingtin protein is mutated in Huntington disease. We previously reported that wild-type but not mutant huntingtin stimulates transcription of the gene encoding brain-derived neurotrophic factor (BDNF; ref. 2). Here we show that the neuron restrictive silencer element (NRSE) is the target of wild-type huntingtin activity on BDNF promoter II. Wild-type huntingtin inhibits the silencing activity of NRSE, increasing transcription of BDNF. We show that this effect occurs through cytoplasmic… CONTINUE READING
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