Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

@article{Zuccato2003HuntingtinIW,
  title={Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes},
  author={C. Zuccato and M. Tartari and A. Crotti and D. Goffredo and M. Valenza and L. Conti and T. Cataudella and B. Leavitt and M. Hayden and T. Timmusk and D. Rigamonti and E. Cattaneo},
  journal={Nature Genetics},
  year={2003},
  volume={35},
  pages={76-83}
}
  • C. Zuccato, M. Tartari, +9 authors E. Cattaneo
  • Published 2003
  • Medicine, Biology
  • Nature Genetics
  • Huntingtin protein is mutated in Huntington disease. We previously reported that wild-type but not mutant huntingtin stimulates transcription of the gene encoding brain-derived neurotrophic factor (BDNF; ref. 2). Here we show that the neuron restrictive silencer element (NRSE) is the target of wild-type huntingtin activity on BDNF promoter II. Wild-type huntingtin inhibits the silencing activity of NRSE, increasing transcription of BDNF. We show that this effect occurs through cytoplasmic… CONTINUE READING
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