Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

@article{Zuccato2003HuntingtinIW,
  title={Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes},
  author={Chiara Zuccato and Marzia Tartari and Andrea Crotti and Donato Goffredo and Marta Valenza and Luciano Conti and Tiziana Cataudella and Blair R. Leavitt and Michael R. Hayden and Tõnis Timmusk and Dorotea Rigamonti and Elena Cattaneo},
  journal={Nature Genetics},
  year={2003},
  volume={35},
  pages={76-83}
}
  • Chiara Zuccato, Marzia Tartari, +9 authors Elena Cattaneo
  • Published 2003
  • Medicine, Biology
  • Nature Genetics
  • Huntingtin protein is mutated in Huntington disease. We previously reported that wild-type but not mutant huntingtin stimulates transcription of the gene encoding brain-derived neurotrophic factor (BDNF; ref. 2). Here we show that the neuron restrictive silencer element (NRSE) is the target of wild-type huntingtin activity on BDNF promoter II. Wild-type huntingtin inhibits the silencing activity of NRSE, increasing transcription of BDNF. We show that this effect occurs through cytoplasmic… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 695 CITATIONS, ESTIMATED 52% COVERAGE

    Sp1 Regulates Human Huntingtin Gene Expression

    VIEW 6 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Repressor element-1 silencing transcription factor (REST) is present in human control and Huntington's disease neurones.

    VIEW 8 EXCERPTS
    CITES BACKGROUND & RESULTS

    MeCP2: a novel Huntingtin interactor.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2002
    2020

    CITATION STATISTICS

    • 51 Highly Influenced Citations

    • Averaged 23 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 26 REFERENCES