Huntingtin-deficient zebrafish exhibit defects in iron utilization and development.

@article{Lumsden2007HuntingtindeficientZE,
  title={Huntingtin-deficient zebrafish exhibit defects in iron utilization and development.},
  author={Amanda L. Lumsden and Tanya L. Henshall and Sonia Dayan and Michael T. Lardelli and Robert I. Richards},
  journal={Human molecular genetics},
  year={2007},
  volume={16 16},
  pages={1905-20}
}
Huntington's disease (HD) is one of nine neurodegenerative disorders caused by expansion of CAG repeats encoding polyglutamine in their respective, otherwise apparently unrelated proteins. Despite these proteins having widespread and overlapping expression patterns in the brain, a specific and unique subset of neurons exhibits particular vulnerability in each disease. It has been hypothesized that perturbation of normal protein function contributes to the specificity of neuronal vulnerability… CONTINUE READING

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