Huntingtin Is Critical Both Pre- and Postsynaptically for Long-Term Learning-Related Synaptic Plasticity in Aplysia

@inproceedings{Choi2014HuntingtinIC,
  title={Huntingtin Is Critical Both Pre- and Postsynaptically for Long-Term Learning-Related Synaptic Plasticity in Aplysia},
  author={Yun-Beom Choi and Beena Kadakkuzha and Xin-an Liu and Komolitdin Akhmedov and Eric R Kandel and Sathyanarayanan V. Puthanveettil},
  booktitle={PloS one},
  year={2014}
}
Patients with Huntington's disease exhibit memory and cognitive deficits many years before manifesting motor disturbances. Similarly, several studies have shown that deficits in long-term synaptic plasticity, a cellular basis of memory formation and storage, occur well before motor disturbances in the hippocampus of the transgenic mouse models of Huntington's disease. The autosomal dominant inheritance pattern of Huntington's disease suggests the importance of the mutant protein, huntingtin, in… CONTINUE READING