Hunting the chameleon: structural conformations of the intrinsically disordered protein alpha-synuclein.

@article{Drescher2012HuntingTC,
  title={Hunting the chameleon: structural conformations of the intrinsically disordered protein alpha-synuclein.},
  author={Malte Drescher and Martina Huber and Vinod Subramaniam},
  journal={Chembiochem : a European journal of chemical biology},
  year={2012},
  volume={13 6},
  pages={761-8}
}
The human a-synuclein protein (ASYN) plays a central role in the etiology of Parkinson's disease,llI and forms fibrillar aggregates that are found in Lewy bodies and Lewy neurites in the brain, structures which are the hallmark of the diseaseY-41 Three point mutations (A30P, AS3T, and E46K)1 are associated with early-onset Parkinson's disease.15-7J… CONTINUE READING