Hunting down huntingtin.

@article{Aronin2012HuntingDH,
  title={Hunting down huntingtin.},
  author={Neil Aronin and Melissa Moore},
  journal={The New England journal of medicine},
  year={2012},
  volume={367 18},
  pages={1753-4}
}
The treatment of neurodegenerative diseases is an unsolved challenge in modern medicine. Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis mostly manifest as sporadic disorders; the exceptional patient inherits the disease. On the other hand, Huntington’s disease (involving dementia, depression, chorea, and years of high-cost care) is an autosomal dominant disease, caused by expansion of a CAG repeat in series near the beginning of the coding region in the gene that… CONTINUE READING