Hunter-gatherer genomes a trove of genetic diversity

  title={Hunter-gatherer genomes a trove of genetic diversity},
  author={E. Callaway},
Sequences from African groups offer genetic clues about disease, height and ancient human breeding. 
1 Citations
Between continuity and discontinuity: An overview of the West African Paleolithic over the last 200,000 years
In Paleolithic settlement models for Africa, West Africa has been neglected, if not entirely ignored, due to an obvious lack of research in the region but also of the availability of reliable andExpand


Evolutionary History and Adaptation from High-Coverage Whole-Genome Sequences of Diverse African Hunter-Gatherers
The whole genomes of five individuals in each of three different hunter-gatherer populations are sequenced and numerous loci that harbor signatures of local adaptation are identified, including genes involved in immunity, metabolism, olfactory and taste perception, reproduction, and wound healing. Expand
Complete Khoisan and Bantu genomes from southern Africa
The extent of whole-genome and exome diversity among the five men, reporting 1.3 million novel DNA differences genome-wide, including 13,146 novel amino acid variants, suggests the Bushmen seem to be more different from each other than, for example, a European and an Asian. Expand
A Draft Sequence of the Neandertal Genome
The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other. Expand
Genetic history of an archaic hominin group from Denisova Cave in Siberia
A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans. Expand
Genetic evidence for archaic admixture in Africa
DNA sequence data gathered from 61 noncoding autosomal regions in a sample of three sub-Saharan African populations are used to test models of African archaic admixture and suggest that polymorphisms present in extant populations introgressed via relatively recent interbreeding with hominin forms that diverged from the ancestors of modern humans in the Lower-Middle Pleistocene. Expand
Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies
Analyzing Illumina 1M SNP array data in three Western Pygmy populations from Cameroon and three neighboring Bantu-speaking agricultural populations with whom they have admixed identifies multiple regions throughout the genome that may have played a role in adaptive evolution. Expand
The Sequence of the Human Genome
Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems are indicated. Expand