Humoral reponse to neuraminidase-treated tumor cells.

L1210 leukemia cells grew progressively and caused tumor deaths in all recipient mice. However, when these cells had been treated with Vibrio cholerae neuraminidase (VCN) prior to injection, tumor deaths did not occur. Both untreated and VCN-treated L1210 cells elicited a humoral response, as manifested by an increasing percent of cells in the spleen and… CONTINUE READING