Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.

@article{Shojima2002HumoralRO,
  title={Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.},
  author={Nobuhiro Shojima and Hideyuki Sakoda and Takehide Ogihara and Midori Fujishiro and Hideki Katagiri and Motonobu Anai and Yukiko Onishi and Hiraku Ono and Kouichi Inukai and Miho Abe and Yasushi Fukushima and Masatoshi Kikuchi and Yoshitomo Oka and Tomoichiro Asano},
  journal={Diabetes},
  year={2002},
  volume={51 6},
  pages={1737-44}
}
Resistin is a hormone secreted by adipocytes that acts on skeletal muscle myocytes, hepatocytes, and adipocytes themselves, reducing their sensitivity to insulin. In the present study, we investigated how the expression of resistin is affected by glucose and by mediators known to affect insulin sensitivity, including insulin, dexamethasone, tumor necrosis factor-alpha (TNF-alpha), epinephrine, and somatropin. We found that resistin expression in 3T3-L1 adipocytes was significantly upregulated… CONTINUE READING
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