Humoral immunity to vimentin is associated with cardiac allograft injury in nonhuman primates.

@article{Azimzadeh2005HumoralIT,
  title={Humoral immunity to vimentin is associated with cardiac allograft injury in nonhuman primates.},
  author={Agnes M Azimzadeh and Steffen Pfeiffer and Guosheng S Wu and Carsten M Schr{\"o}der and Hui Zhou and George L Trip Zorn and Marilyn R. Kehry and Geraldine G. Miller and Marlene L. Rose and Richard N Pierson},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2005},
  volume={5 10},
  pages={2349-59}
}
Immunity to autologous protein has not previously been described following nonhuman primate cardiac transplant. Native hearts and cardiac allografts from cynomolgus monkeys were assessed by immunohistology for vimentin, a highly conserved intermediate filament protein. IgM and IgG to vimentin were measured in serial sera from untreated (n = 4) or cyclosporine (CsA)-treated (n = 8, 2 with ATG) cardiac allograft recipients, and in groups treated with anti-CD154 antibody with (n = 6) or without… CONTINUE READING