Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point.

@article{Trkola2004HumoralIT,
  title={Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point.},
  author={Alexandra Trkola and Herbert Kuster and Christine Leemann and Annette Oxenius and Catherine Fagard and Hansjakob Furrer and Manuel Battegay and Pietro Vernazza and Enos Bernasconi and R. Neal Weber and Bernard Hirschel and Sebastian Bonhoeffer and Huldrych F. G{\"u}nthard},
  journal={Blood},
  year={2004},
  volume={104 6},
  pages={
          1784-92
        }
}
We analyzed the humoral immune response in 46 patients following structured treatment interruption (STI) to investigate the general potential of therapeutic vaccination in chronic HIV-1 infection. Evoked antibody titer increases to glycoprotein 120 (gp120) and p24 were low during 4 short-term STIs and only reached significance during a fifth long-term interruption. Although induction of binding antibodies to viral antigens was not associated with potent suppression of viremia, we observed that… CONTINUE READING

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