Humoral immunity in brain aging and Alzheimer's disease

  title={Humoral immunity in brain aging and Alzheimer's disease},
  author={Constantin Bouras and B{\'e}at Michel Riederer and E K{\"o}vari and Patrick R. Hof and Panteleimon Giannakopoulos},
  journal={Brain Research Reviews},
Although the contribution of inflammatory processes in the etiology of late-onset Alzheimer's disease (AD) has been suspected for years, most studies were confined to the analysis of cell-mediated immunological reactions thought to represent an epiphenomenon of AD lesion development. Based on the traditional view of the "immunological privilege" of the brain, which excludes a direct access of human immunoglobulins (Ig) to the central nervous system under normal conditions, little attention has… CONTINUE READING

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