Humoral immune responses to Neisseria meningitidis in children.

  title={Humoral immune responses to Neisseria meningitidis in children.},
  author={Andrew J Pollard and Rachel Galassini and Ella van der Voort and Robert Booy and Paul Langford and Simon Nadel and Catherine Ison and J. Simon Kroll and Jan T. Poolman and M Levin},
  journal={Infection and immunity},
  volume={67 5},
An understanding of the nature of immunity to serogroup B meningococci in childhood is necessary in order to establish the reasons for poor responses to candidate vaccines in infancy. We sought to examine the nature of humoral immune responses following infection in relation to age. Serum bactericidal activity was poor in children under 12 months of age despite recent infection with Neisseria meningitidis. The highest levels of bactericidal activity were seen in children over 10 years of age… CONTINUE READING