Humoral immune responses of Solomon Islanders to the merozoite surface antigen 2 of Plasmodium falciparum show pronounced skewing towards antibodies of the immunoglobulin G3 subclass.

@article{Rzepczyk1997HumoralIR,
  title={Humoral immune responses of Solomon Islanders to the merozoite surface antigen 2 of Plasmodium falciparum show pronounced skewing towards antibodies of the immunoglobulin G3 subclass.},
  author={Christine M. Rzepczyk and Kristina Hale and N Woodroffe and A Bobogare and Peter A. Csurhes and Akira Ishii and Antonio Ferrante},
  journal={Infection and immunity},
  year={1997},
  volume={65 3},
  pages={1098-100}
}
The immunoglobulin G (IgG) subclass distribution of antibodies to merozoite surface antigen 2 of Plasmodium falciparum in Solomon Islanders showed marked skewing towards the IgG3 subclass. This was not observed with crude P. falciparum schizont antigen. IgG3 responses may be short-lived and require repeated restimulation for their maintenance. This may be provided by persistent infection (premunition) or new infections.